Overview
Monte Rosa Therapeutics (MRT) seeks to recruit an enthusiastic, creative and highly talented medicinal chemist who is eager to discover molecular glue degraders (MGDs) that eliminate disease-causing proteins previously thought undruggable.
This position plays a key role in contributing to the development of our growing portfolio and will have a crucial impact at the forefront of drug discovery. The successful candidate should have strong interest in early-stage drug discovery, prior experience in HTS data analysis, hit follow-up as well as utilizing state-of-the-art medicinal chemistry knowledge.
Responsibilities
- Analyze High Throughput Screening (HTS) output with the goal of identifying promising starting points for hit generation chemistry from our growing MGD library.
- Serve as a chemistry project lead against multiple early-stage projects across different disease area.
- Develop hit follow up and lead generation strategy for discovery targets in collaboration with discovery scientists.
- Create structure activity relationship driven hypotheses for follow-up experiments to probe target engagement in hit validation.
- Provide tool compounds and contribute to target validation efforts as member of a cross-functional discovery team.
- Provide chemistry progressability assessments for early targets.
- Familiarity with key concepts and optimization strategies in medicinal chemistry including a clear understanding of ADME properties.
- Efficient and timely execution of compound syntheses through our CRO network, by devising efficient synthetic routes.
- Collaborate with external research partners.
- Communicate scientific findings and project updates to senior leadership and governance.
- Summarize and publish findings in manuscripts and patents when appropriate.
Qualifications
- PhD in synthetic organic/medicinal chemistry with 5+ years of experience in pharmaceutical/biotech industry, or MS with 12+ years of experience is acceptable.
- Deep experience of High Throughput Screening analysis and follow-up.
- Familiarity with early stages of pre-clinical research in drug discovery.
- Experience of collaborating with CROs is essential.
- High level of proficiency with databases, data analysis and visualization tools (e.g. Spotfire, D360, CDD, Maestro, Pymol).
- Proficiency in complex molecule synthesis and/or synthetic method development experience.
- Proficiency in complex molecule synthesis and/or synthetic method development experience.
- Apply state-of-the-art medicinal chemistry design principles to MGD discovery
- Excellent teamwork skills and the ability to work effectively in global, cross-disciplinary drug discovery teams (biochemistry, biology, structural biology, CADD, and DMPK).
- Communicate scientific findings and project updates to senior leadership and governance.
- Excellent written and oral communication skills.